In this report, the Global In Vivo Contract Research Organizations (CROs) Market has been segmented by Modality, GLP Type, Product Type, Applications and Geography.

Global In Vivo Contract Research Organizations (CROs) Market, Segmentation by Modality

The Global In Vivo Contract Research Organizations (CROs) Market has been segmented by Modality into Smalll Molecules Modality, and Large Molecules Modality.

The Small Molecules Modality segment represents approximately 60% of the global in vivo CROs market. This segment specializes in preclinical and clinical research for small-molecule drug candidates, benefiting from standardized protocols, scalability, and diverse therapeutic applications. Its continued dominance is driven by its adaptability across a wide range of indications.

The Large Molecules Modality segment contributes around 40% of the global market. Encompassing biologics like monoclonal antibodies, proteins, and cell therapies, this segment is expanding rapidly due to rising demand for innovative biologic drugs and the need for advanced in vivo testing services to support complex therapeutic development.

Global In Vivo Contract Research Organizations (CROs) Market, Segmentation by GLP Type

The Global In Vivo Contract Research Organizations (CROs) Market has been segmented by GLP Type into Non GLP and GLP Toxicology.

The Non GLP segment accounts for around 40% of the global in vivo CROs market. This category covers exploratory research and early-stage proof-of-concept studies, essential for evaluating the potential of new drug candidates. These studies help de-risk later-stage development by identifying promising compounds before formal regulatory submissions.

The GLP Toxicology segment contributes approximately 60% of the market. It encompasses comprehensive studies conducted under Good Laboratory Practice (GLP) standards, ensuring compliance and data integrity for regulatory submissions. This segment plays a crucial role in advancing drug candidates through the preclinical pipeline.

Global In Vivo Contract Research Organizations (CROs) Market, Segmentation by Product Type

The Global In Vivo Contract Research Organizations (CROs) Market has been segmented by Product Type into Rodent Based and Non Rodent Based.

The Rodent Based segment dominates the global in vivo CROs market with around 70% share. Rodents, including mice and rats, are extensively used for preclinical research due to their genetic similarity to humans, low cost, and ability to model a wide range of diseases. Their widespread use makes them a cornerstone of preclinical drug testing.

The Non Rodent Based segment holds approximately 30% of the market. This category involves using larger animal models such as dogs and non-human primates, which are critical for certain complex and translational studies. Their use ensures regulatory compliance and robust data generation for advancing therapies into human trials.

Global In Vivo Contract Research Organizations (CROs) Market, Segmentation by Applications

The Global In Vivo Contract Research Organizations (CROs) Market has been segmented by Applications into Autoimmune, Pain Management, Oncology, CNS Conditions, Diabetes, Obesity and Others.

The Autoimmune segment contributes about 20% to the global in vivo CROs market. This segment is driven by the increasing prevalence of autoimmune diseases and the need for animal models to explore disease mechanisms and test innovative therapies, supporting preclinical research advancements.

The Pain Management segment holds nearly 10% of the market. Focused on developing and evaluating new analgesic treatments, it utilizes in vivo models to assess drug efficacy and safety in managing various pain conditions.

The Oncology segment leads with approximately 30% of the total market share. The rising global incidence of cancer and the continuous push for novel oncology therapeutics make this segment a cornerstone of preclinical research services offered by CROs.

The CNS Conditions segment represents around 15% of the market. This segment focuses on studying central nervous system disorders, including Alzheimer’s, Parkinson’s, and epilepsy, through specialized in vivo models to understand disease progression and therapeutic potential.

The Diabetes segment holds about 10% of the market. It supports the development of antidiabetic drugs by utilizing animal models to study insulin resistance, glucose metabolism, and potential treatments for diabetes management.

The Obesity segment contributes roughly 5% to the market. It focuses on preclinical research into weight management therapies and metabolic conditions, using animal models to simulate human obesity for therapeutic development.

The Others segment captures approximately 10% of the market. This diverse category includes research into rare diseases, infectious diseases, and regenerative therapies, reflecting the growing breadth of in vivo CRO applications.

Global In Vivo Contract Research Organizations (CROs) Market, Segmentation by Geography

In this report, the Global In Vivo Contract Research Organizations (CROs) Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East and Africa and Latin America.

Global In Vivo Contract Research Organizations (CROs) Market Share (%), by Geographical Region, 2024

The North America segment commands around 40% of the global in vivo CROs market. Strong research infrastructure, high investment in pharmaceutical R&D, and a supportive regulatory framework drive the region’s leadership in advanced in vivo preclinical research services.

Europe contributes nearly 30% to the market, supported by established research institutions, robust government funding, and a focus on reducing animal testing through advanced in vivo models. Collaborative efforts between academia and CROs further fuel growth.

The Asia Pacific segment holds about 20% of the market. Growing investment in biopharmaceutical R&D, expanding CRO networks, and rising demand for cost-effective research solutions are key drivers of regional expansion in countries such as China, India, and Japan.

Middle East and Africa capture around 5% of the market. Ongoing improvements in healthcare infrastructure, increasing collaborations with international CROs, and heightened awareness of advanced research methodologies contribute to gradual market growth.

Latin America represents approximately 5% of the market. Expanding pharmaceutical industries, favorable regulatory environments, and growing outsourcing of preclinical research are fueling regional growth, particularly in countries like Brazil and Argentina.

This report provides an in depth analysis of various factors that impact the dynamics of Global In Vivo Contract Research Organizations (CROs) Market. These factors include; Market Drivers, Restraints and Opportunities Analysis.

Drivers, Restraints and Opportunity Analysis

Drivers

• Advancements in Biopharmaceutical Research
• Extensive Use of In Vivo Studies

• Increased Focus on Biologics - Increased focus on biologics is a major driver of growth in the global in vivo contract research organizations (CROs) market. Biologics, including monoclonal antibodies, cell therapies, and gene therapies, require complex and highly specialized preclinical testing to evaluate efficacy, safety, and immune response in living models. As pharmaceutical and biotech companies expand their biologics pipelines, they increasingly rely on in vivo CROs with advanced capabilities and regulatory expertise to support the development process.

  In vivo CROs offer the infrastructure, technologies, and experience needed to conduct rigorous animal model testing aligned with global standards. The growing demand for precision testing in biologics—along with rising R&D investments and a shift toward outsourcing strategies—is driving long-term market growth. These services accelerate time-to-market and allow sponsors to focus on core innovation while ensuring compliance and data integrity.

Restraints

• Ongoing Regulatory Approval Challenges
• Significant Biopharma Cost Constraints

• Prevailing Ethical Research Concerns - Prevailing ethical research concerns serve as a significant restraint in the global in vivo contract research organizations (CROs) market. The use of animal models in preclinical research often raises public and institutional scrutiny over animal welfare, testing justifiability, and transparency in research practices. These concerns have prompted the implementation of stricter ethical guidelines and increased pressure on CROs to justify the scientific necessity of animal studies, adding complexity to study design and approval processes.

  Compliance with animal rights regulations and global standards such as the 3Rs principle—Replacement, Reduction, and Refinement—requires significant investment in infrastructure, monitoring, and reporting. Failure to meet ethical expectations can lead to reputational damage, regulatory delays, or even trial discontinuation. As advocacy for alternative testing models gains traction, in vivo CROs may face limitations in scalability and broader market acceptance unless they adopt more transparent, ethically sound practices.

Opportunities

• Advancements in Biosimilar Development
• Widespread Use of Monoclonal Antibodies

• Emerging Focus on Bispecific Antibodies - The emerging focus on bispecific antibodies offers strong growth potential for the global in vivo contract research organizations (CROs) market. These advanced biologics, capable of binding to two different targets simultaneously, are gaining momentum in the treatment of cancer, autoimmune diseases, and other complex conditions. Their unique mechanisms require detailed in vivo studies to assess efficacy, safety, and immune interactions, driving demand for CROs with advanced preclinical capabilities.

  With an expanding pipeline of bispecific therapeutics, pharmaceutical and biotech companies are increasingly outsourcing preclinical testing to specialized CROs. These organizations provide access to customized animal models, humanized systems, and regulatory expertise, all of which are essential for accelerating development. As bispecifics become central to biologic innovation, in vivo CROs are well-positioned to capitalize on this growing market segment.

Key players in Global In Vivo Contract Research Organizations (CROs) Market include:

• PPD Inc
• Quintiles
• ICON Plc
• Parexel International Corporation
• American Preclinical Services
• LLC
• Labcorp Drug Development
• Theorem Clinical research
• WuXi AppTec
• Syneos Health
• Evotec
• Charles River Laboratories

In this report, the profile of each market player provides following information:

• Company Overview
• Market Share Analysis
• Key Developments
• Financial Overview
• Strategies
• Company SWOT Analysis